Stevens-Johnson syndrome (SJS) is an acute blistering disease of the skin and mucous membranes and can cause severe eye problems. The most common cause of this condition is an adverse allergic drug reaction. More common in children and young adults, acute SJS leads to acute inflammation of the ocular surface, chronic conjunctivitis, corneal blisters and perforation which can lead to permanent vision loss. The destruction of the glands that secrete the tear film leads to a severe form of dry eye that makes the management of chronic SJS difficult.The treatment therapy includes ocular lubrication with artificial tears and ointments and frequent surveillance of ocular infections. Corneal transplants, limbal stem cell transplantations or artificial corneal procedures may also be considered.